Persistent fatigue is a tough mystery to solve. Causes include anemia, anxiety, depression, infection, cancer, chronic fatigue syndrome (CFS), poor diet, too little or too much exercise, poor sleep, liver or kidney disease, and the list goes on. One of the most overlooked conditions that can cause fatigue is autoimmune gastritis— a chronic inflammatory disease in which the immune system mistakenly destroys parietal cells— cells that produce the stomach acid and intrinsic factor (IF), which the body needs to be able to absorb vitamin B12.
As a result, people with autoimmune gastritis often suffer from pernicious anemia — a condition in which the body is unable to absorb the vitamin B12 needed to manufacture healthy red blood cells. Without sufficient numbers of healthy red blood cells to carry oxygen throughout the body, it is no surprise that people with pernicious anemia suffer persistent fatigue.
When we think about autoimmunity, a few specific conditions come to mind including rheumatoid arthritis (RA), multiple sclerosis (MS), juvenile diabetes, hyperthyroid, and Lupus. Of course, there are others.
What we don’t often consider are the less discussed or less aggressive autoimmune conditions that can have a large impact of how we feel day to day, lead to more progressive illness, and are often associated with the development of additional autoimmune conditions.
Unfortunately, conventional medical doctors often overlook autoimmune gastritis in patients who report chronic fatigue. They may test for anemia and treat it with iron supplements or test for B12 deficiency, see that your B12 level is fine, and never consider whether your body is actually able to absorb and use that B12. Even worse, some people who report fatigue are simply diagnosed as having Continue reading…